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De aktive stoffer buprenorphin og nalbuphin er midler der virker som de andre syntetiske opioider, Males de har desuden en modsatrettet virkning, idet de også spærrer for andre opioiders virkning.Fra gammel tid har guy anvendt udtræk fra opiumsvalmuen i smertebehandling og disse midler er baseret på naturlige opioider eller de er kunstigt frems